CBD and Alzheimer's: What Does Science Say?
Introduction
Alzheimer's disease is one of the most common forms of dementia, a progressive neurodegenerative disease that affects memory, language, behavior, and cognitive abilities. Currently, there is no definitive cure, but research is constantly seeking complementary therapies that can slow the progression of the disease or improve patients' quality of life.
Among the emerging natural solutions, CBD (cannabidiol) has attracted attention for its neuroprotective and anti-inflammatory effects. But what does science really say about the relationship between CBD and Alzheimer's ?
What is CBD?
CBD is a natural, non-psychoactive compound extracted from the cannabis plant. Unlike THC, it doesn't cause "intoxicating" effects, but it interacts with the human body's endocannabinoid system , influencing functions such as:
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Inflammation
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Perception of pain
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Sleep
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Humor
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Memory and neuroprotection
Thanks to these properties, CBD is the subject of numerous studies related to neurodegenerative diseases, including Alzheimer's.
CBD and Alzheimer's: What are the Potential Benefits?
π§ 1. Neuroprotective effect
CBD has shown protective effects on neurons in several preclinical studies. By interacting with CB1 and CB2 receptors, it may help reduce cell death caused by oxidative stress and the accumulation of beta-amyloid, the protein associated with the progression of Alzheimer's disease.
π¬ A study published in the Journal of Alzheimer's Disease showed that CBD significantly reduced the accumulation of toxic proteins in animal models.
π Source
π₯ 2. Anti-inflammatory action
Chronic inflammation in the brain (neuroinflammation) is a major hallmark of Alzheimer's disease. CBD has anti-inflammatory properties that may counteract this pathological mechanism, reducing neuronal damage.
π 3. Control of behavioral symptoms
In the advanced stages of the disease, many patients develop agitation, anxiety, aggression, and sleep disturbances . CBD may help reduce these symptoms, improving the quality of life for patients and caregivers.
π§ͺ A 2019 study found that CBD reduced irritability and improved sleep in elderly patients with dementia.
π Source
How could CBD be used in Alzheimer's patients?
While the evidence is still developing, CBD is commonly administered in the following forms:
| Form of CBD | Advantages | How to use |
|---|---|---|
| Sublingual oil | Rapid absorption and flexible dosing | Place under the tongue, 1-2 times a day |
| Capsule | Precise dosage and convenience | Ideal for regular use |
| Topical creams | For muscle tension and local ailments | Local use, not recommended for Alzheimer's |
| Edibles / Herbal Teas | Gentle and gradual intake | Suitable for those who have difficulty taking medications |
π Important note : The dosage should always be evaluated by a doctor, especially if the patient is already taking other medications (e.g. antipsychotics or sedatives).
Is CBD safe for seniors?
In general, CBD is well tolerated even in older people , but mild side effects may occur, such as:
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Drowsiness
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Dry mouth
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Reduction of appetite
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Interactions with other drugs
It is essential to use certified products, with adequate dosages, preferably under medical supervision.
What Does the Research Say?
The scientific community is still exploring the full potential of CBD in treating Alzheimer's. Although many studies are in the preclinical stage (on animals or in vitro), preliminary results are encouraging.
Some ongoing studies are evaluating the effectiveness of CBD in combination with other cannabinoids (such as THC in minimal doses) to improve therapeutic outcomes. However, large-scale clinical trials are still needed to obtain more robust evidence.
Conclusion
CBD may represent a promising complementary strategy for addressing the symptoms of Alzheimer's, thanks to its neuroprotective, anti-inflammatory, and anxiolytic properties. It is not a cure, but a natural support that could improve the quality of life of patients and their families.
Before starting any treatment with CBD, it is essential to consult your doctor or neurologist , especially if you are undergoing other pharmacological therapies.
π Scientific sources
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Watt G, Karl T. (2017) In vivo Evidence for Therapeutic Properties of Cannabidiol (CBD) for Alzheimer's Disease . Front Pharmacol.
π https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5520879/ -
Cheng D et al. (2014) Cannabidiol reduces AΞ²-induced neuroinflammation and promotes neurogenesis . Journal of Alzheimer's Disease.
π https://pubmed.ncbi.nlm.nih.gov/30452123/ -
Walther S et al. (2019) Cannabinoids in the treatment of agitation in Alzheimer's disease . Therapeutic Advances in Psychopharmacology.
π https://pubmed.ncbi.nlm.nih.gov/30800357/